1. MotivationPractically all chemotherapeutic agents and potentially many targeted therapies that are used in the clinical treatment of cancer lead to drug resistance. There is, however, no consensus on whether drug resistance is pre-existing or acquired. Pre-existing drug resistance means the cancer contains a subpopulation of drug resistant ce...
Creator:
Gevertz, Jana (The College of New Jersey); Rejniak, Katarzyna Anna (Moffitt Cancer Center)
Created:
2013-09-09
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
Clustering is a stable phase-locked activity pattern that has been observed in networks of intrinsically oscillating neurons. In these states the network breaks up into clusters. Neurons within a cluster exhibit phase-locked behavior with zero phase-lag, while between clusters neurons are phase-locked with non-zero phase-lag. Clustering has been...
Creator:
Booth, Victoria (University of Michigan); Campbell, Sue Ann (University of Waterloo)
Created:
2013-09-09
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
1. Motivation of the ProblemIntermittent preventive treatment (IPT) describes the process in which a full therapeutic course of anti-malarial drug is administered to individuals most vulnerable to malaria effects, regardless of their infection state. IPT usage is increasingly being utilized as a means of preventing malaria in these at risk human...
Creator:
Feng, Zhilan (Purdue University); Teboh-Ewungkem, Miranda Ijang (Lehigh University)
Created:
2013-09-09
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
The QuestionsAnti-coagulation therapy is often prescribed after surgery in order to preventthe formation of dangerous clots that could cause strokes or respiratory obstructions. However, the clotting properties of blood are naturally tightly regulated by the healthy body, and these treatments can upset these innate regulatory processes. Furtherm...
Creator:
de Pillis, Lisette (Harvey Mudd College); Graham, Erica (North Carolina State University); Radunskaya, Ami (Pomona College)
Created:
2013-09-09
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
What is autoregulation?Autoregulation is a biological process in which an internal adaptive mechanism works to adjust (or miti-gate) an animal's response to stimuli. For example, the autoregulation process results in the maintenance of blood flow to tissues at a certain level despite variations in blood pressure or metabolism. Autoregulation is ...
Creator:
Arciero (Sparks); Julia C. (Indiana University-Purdue University); Layton, Anita (Duke University)
Created:
2013-09-09
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
Recent developments in microfluidic devices have enabled controlled studies and manipulation of fluid flows with length scales at the micron level [6]. At this length scale, viscous forces are very important and processes such as diffusion and surface tension dominate. In many microfluidic experiments that measure chemical and biological process...
Creator:
Fauci, Lisa J. (Tulane University); Leiderman, Karin (University of California, Merced)
Created:
2013-09-09
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
During sleep, we experience a loss of consciousness coupled with decreased muscle tone and increased sensory thresholds. Yet sleep is not a uniform state. For most mammals, sleep involves alternations between the rapid eye movement (REM) sleep in which we have our most vivid dreams and non-rapid eye movement (NREM) sleep including deep slow wave...
Creator:
Best, Janet (The Ohio State University); Huguet, Gemma (Universitat Politecnica de Catalunya)
Created:
2013-09-09
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
Phototransduction cascades transform light to electrical signals that project to the brain through a sequence of chemical reactions. Image forming vertebrate vision is facilitated by rods and cones in the back of the retina, each of which has its own opsin, a light sensitive G-protein coupled receptor. Recently a third opsin, melanopsin, was ide...
Creator:
Hoffman, Kathleen (University of Maryland Baltimore County); Kang, Hye-Won (University of Maryland Baltimore County)
Created:
2013-09-09
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.