Motor proteins, such as kinesins and dyneins, are responsible for several fundamental transport functions inside the cell. Disruptions of these underlying mechanisms are linked to many neurodegenerative diseases such as Alzheimer's, Paraplegia and Amyotrophic Lateral Sclerosis (ALS). Impaired functionality of motor proteins, possibly caused due ...
Creator:
Bhaban, Shreyas (University of Minnesota, Twin Cities)
Created:
2015-11-20
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
It has recently been shown that structural conditions on the reaction network, rather than a €˜fine-tuning' of system parameters, often suffice to impart €˜absolute concentration robustness' on a wide class of biologically relevant, deterministically modeled mass-action systems [Shinar and Feinberg, Science, 2010]. Many biochemical networks, how...
Creator:
Enciso, German (University of California, Irvine)
Created:
2015-11-20
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
Oscillations of populations of neurons deep in the brain are thought to be responsible for some of the symptoms for Parkinson's Disease. Drugs and deep brain stimulation that re used to treat Parkinson's Disease suppress these oscillations. We have developed methods to measure how the oscillations are modulated by stimulation, to generate a phas...
Creator:
Netoff, Theoden (University of Minnesota, Twin Cities)
Created:
2015-11-20
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
Boolean networks are an important class of computational models for molecular interaction networks. Boolean canalization, a type of hierarchical clustering of the inputs of a Boolean function, has been extensively studied in the context of network modeling where each layer of canalization adds a degree of stability in the dynamics of the network...
Creator:
Murrugarra, David (University of Kentucky)
Created:
2015-11-20
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
The inherent stochastic nature of biochemical processes can drive differences in gene expression between otherwise identical cells. While cell-to-cell variability in gene expression has received much attention, randomness in timing of events has been less studied. We investigate event timing at the single-cell level in a simple system, the lytic...
Creator:
Singh, Abhyudai (University of Delaware)
Created:
2015-11-20
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
Signaling networks that convert graded stimuli into binary, all-or-none cellular responses are critical in processes ranging from cell-cycle control to lineage commitment. To exhaustively enumerate topologies that exhibit this switch-like behavior, we simulated all possible two- and three-component networks on random parameter sets, and assessed...
Creator:
Sarkar, Casim (University of Minnesota, Twin Cities)
Created:
2015-11-20
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
Interval graphs are interesting cases because a biologist first developed them, and the formal mathematics to explore them was developed later. Interval graphs have a variety of biological applications across broad samplings of phylogenetic diversity, spatial and temporal scales, and diverse biological mechanisms. An important property of interv...
Creator:
Jungck, John R (University of Delaware)
Created:
2015-11-20
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
Practical applications in modern molecular and systems biology, such as the search for new therapeutic targets for diseases and stem cell reprogramming, have generated a great interest in the cell fate reprogramming, i.e., controlling the internal state of a cell so that it is driven from an initial state to a final target state. Although the to...
Creator:
G. T. Zañudo, Jorge (The Pennsylvania State University)
Created:
2015-11-20
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.