Covariate-adjusted randomization procedure is frequently used in comparative studies (such as clinical trials for precision medicine) to increase the covariate balance across treatment groups. However, as the randomization inevitably uses the covariate information when forming balanced treatment groups, the validity of classical statistical meth...
Creator:
Hu, Feifang (George Washington University)
Created:
2018-11-08
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
Biomedical knowledge graphs represent relations among biomedical entities and have been intensively analyzed for drug repositioning, disease gene discovery and other important medical applications. While most existing studies focus on analyzing and predicting pairwise relations, we consider learning multi-relations among the entities across many...
Creator:
Kuang, Rui (University of Minnesota, Twin Cities)
Created:
2018-11-08
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
Mediation analysis has been commonly used to study the effect of an exposure on an outcome through a mediator. In practice, we may face the problem to estimate and test a specific mediator of interest, termed “targeted" mediator, in the presence of high dimensional mediators. In this talk we present a de-biased Lasso estimate for the targeted ...
Creator:
Liu, Lei (Washington University School of Medicine)
Created:
2018-11-08
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
To, effectively, combat the opioid epidemic and associated infectious diseases we must elucidate factors associated with therapeutic initiation, adherence and completion of therapy. However, the patient population compounds the problem of elucidation of these factors. Substance users are characterized by lack of medical care, generally limited f...
Creator:
Markatou, Marianthi (University at Buffalo (SUNY))
Created:
2018-11-08
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
A key issue in precision medicine is to uncover and utilize interactions between treatments and one's genetic and environmental risk factors. Due to the polygenic nature, testing for the interaction between a treatment and one's genetic features like a set of SNPs involves testing on a high-dimensional parameter. For such a purpose, it is critic...
Creator:
Pan, Wei (University of Minnesota, Twin Cities)
Created:
2018-11-08
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
Identification of subgroups in a biomedical study with subjects sampled from a heterogeneous population has attracted considerable attention in recent years. Technically, subgroup group analysis may be formulated as a type of supervised clustering analysis with group labels being latent. The method of finite mixture model is the most widely used...
Creator:
Song, Peter (University of Michigan)
Created:
2018-11-08
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
Hypothesis testing to compare dynamic treatment regimes (DTR) from a sequential multiple assignment randomization trial (SMART) is generally based on inverse probability weighting or g-estimation. However, regression methods allowing for comparison of DTRs that flexibly adjust for baseline covariates using these methods are not as straight-forwa...
Creator:
Wahed, Abdus (University of Pittsburgh)
Created:
2018-11-08
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
Over the past decade, there has been a remarkable improvement in our understanding of the role of genetic variation in complex human diseases. Discovery the genetic variants that have significant associations with various diseases, phenotypes and treatment responses is the key step towards the development of precision therapeutic interventions. ...
Creator:
Wei, Ying (Columbia University)
Created:
2018-11-08
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.