Nonsense-mediated mRNA decay (NMD) is a cellular RNA surveillance systemthat recognizes transcripts with premature termination codons and degradesthem. We previously discovered large numbers of natural alternative spliceforms that appear to be targets for NMD, and we speculated that this mightbe a mode of gene regulation which we termed RUST (re...
Creator:
Brenner, Steven (University of California, Berkeley)
Created:
2007-10-31
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
This talk is focused on recent developments within the field of topoly optimization, e.g. optimal material distribution. The main focus concerns the current state-of-the-art, which is that large structural systems has until now been dealing mainly with the design of individual parts - and not with complete assemblies or structures. In this talk ...
Creator:
Aage, Niels (Technical University of Denmark)
Created:
2016-06-08
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
The Gromov-Hausdorff (GH) distance provides a flexible notion of dissimilarity between datasets. It is known that computing the GH distance between finite metric spaces leads to NP-Hard computational problems. This is true even for finite ultrametric spaces, which are highly structured metric spaces satisfying the so-called 'strong' triangle ine...
Creator:
Mémoli, Facundo (The Ohio State University)
Created:
2021-02-23
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
Solvers for coupled multi-scale (multi-physics) may be constructed bycoupling an array of existing and well tested parallel numericalsolvers, each designed to tackle a problem at different spatial andtemporal scale. Each solver can be optimized/designed for differentcomputer architecture. Future supercomputers may be composed ofheterogeneous pro...
Creator:
Grinberg, Leopold (Brown University)
Created:
2011-01-13
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
Plasticity in metals and alloys is a mature discipline in the mechanics of materials. However, it appears that current theoretical modeling lacks predictive power. If a new form of steel, say, is fabricated, there appears to be no way of predicting its deformation and fracture behavior as a function of temperature, and/or cyclic loading. The roo...
Creator:
Lund, Fernando (University of Chile)
Created:
2008-07-23
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.
